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Diabetes

Zafgen Abandons Belanorib Program But Continues Exploring MetAP2 Inhibitor For Obesity

Posted July 22, 2016 by Arya M. Sharma, MD

Regular readers may recall previous posts on the novel anti-obesity compound belanorib, a MetAP2 inhibitor that showed remarkable weight loss efficacy both in patients with Prader-Willi Syndrome as well as hypothalamic obesity. Unfortunately, as noted before, several cases of venous thromoboembolisms led to a halt of ongoing trials during which the company (Zafgen) sought to better understand the … Read More »

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Diabetes

Fructose-Sweetened Beverages Do Not Promote Systemic Inflammation

Posted July 13, 2016 by Arya M. Sharma, MD

There is little doubt that increased consumption of fructose-sweetened beverages can be a substantial source of extra calories, thereby potentially promoting weight gain. That said, fructose has also been implicated in non-caloric metabolic effects including promoting insulin resistance and systemic inflammation. Now a study by Jessica Kuzma and colleagues from the Fred Hutchinson Cancer Research … Read More »

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Diabetes

Does Glycemic Response to Food Really Affect Appetite?

Posted July 12, 2016 by Arya M. Sharma, MD

A popular narrative by proponents of low-glycemic index foods is the notion that high-glycemic index foods lead to a surge in plasma glucose, which in turn stimulates a spike in insulin levels, resulting in a rapid drop in blood glucose levels and an increase in appetite (“crash and crave”). While this narrative is both biologically plausible and has been popularised by countless low-G… Read More »

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Addictions

“Jeunesse,” miracle cure?

Posted March 9, 2015 by Allan W Janssen

Dear Readers: As you may know I just spent ten weeks in the hospital, four of them on life support, for complications from the flu! My recover has been sporadic until I tried this product from “Jeunesse.” They call it “Reserve” and it is a combination of many natural occurring substances that slow aging and […]

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